Drugs for Epilepsy p. 9
Treatment of epilepsy should begin with a single
drug, increasing the dosage gradually until seizures
are controlled or adverse effects become unacceptable.
If seizures persist, expert clinicians generally
prescribe at least one and sometimes a second alternative
drug as monotherapy before considering use of
two drugs at the same time. When used for the appropriate
seizure type, antiepileptic drugs are roughly
equivalent in efficacy. The choice of drug is usually
based on factors such as ease of use, adverse effects,
interactions with other drugs, presence of comorbid
conditions and cost.