The Medical Letter on Drugs and Therapeutics
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ISSUE1659
ISSUE1659
September 19, 2022
Lipid-Lowering Drugs
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Lipid-Lowering Drugs
September 19, 2022 (Issue: 1659)
Cholesterol management guidelines from the
American College of Cardiology/American Heart
Association Task Force were last published in 2019.
- SM Grundy et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. J Am Coll Cardiol 2019; 73:e285.
- US Preventive Services Task Force. Statin use for the primary prevention of cardiovascular disease in adults. US Preventive Services Task Force recommendation statement. JAMA 2022; 328:746.
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- Alirocumab (Praluent) to lower LDL-cholesterol. Med Lett Drugs Ther 2015; 57:113.
- Evolocumab (Repatha) – a second PCSK9 inhibitor to lower LDL-cholesterol. Med Lett Drugs Ther 2015; 57:140.
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- Inclisiran (Leqvio) for LDL-cholesterol lowering. Med Lett Drugs Ther 2022; 64:43.
- KK Ray et al. Two phase 3 trials of inclisiran in patients with elevated LDL cholesterol. N Engl J Med 2020; 382:1507.
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- Bempedoic acid (Nexletol) for lowering LDL cholesterol. Med Lett Drugs Ther 2020; 62:53.
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- CM Ballantyne et al. Bempedoic acid plus ezetimibe fixed-dose combination in patients with hypercholesterolemia and high CVD risk treated with maximally tolerated statin therapy. Eur J Prev Cardiol 2020; 27:593.
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- HB Rubins et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. N Engl J Med 1999; 341:410.
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- HPS2-THRIVE Collaborative Group. Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med 2014; 371:203.
- FJ Raal et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial. Lancet 2015; 385:341.
- Two new drugs for homozygous familial hypercholesterolemia. Med Lett Drugs Ther 2013; 55:25.
- FJ Raal et al. Evinacumab for homozygous familial hypercholesterolemia. N Engl J Med 2020; 383:711.
- Evinacumab (Evkeeza) for homozygous familial hypercholesterolemia. Med Lett Drugs Ther 2021; 63:66.
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Title: Lipid-Lowering Drugs
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