Delgocitinib Cream (Anzupgo) for Chronic Hand Eczema
Delgocitinib Cream (Anzupgo) for Chronic Hand Eczema
October 13, 2025 (Issue: 1739)
The FDA has approved a 2% cream formulation of
delgocitinib (Anzupgo – Leo), a Janus kinase (JAK)
inhibitor, for treatment of moderate to severe chronic
hand eczema (dermatitis) in adults who had an
inadequate response to or are unable to use...more
- Ruxolitinib (Opzelura) for atopic dermatitis. Med Lett Drugs Ther 2022; 64:12.
- JP Thyssen et al. Guidelines for diagnosis, prevention, and treatment of hand eczema. Contact Dermatitis 2022; 86:357. doi:10.1111/cod.14035
- E Weisshaar. Chronic hand eczema. Am J Clin Dermatol 2024; 25:909. doi:10.1007/s40257-024-00890-z
- EL Simpson et al. Dupilumab treatment improves signs, symptoms, quality of life, and work productivity in patients with atopic hand and foot dermatitis: results from a phase 3, randomized, double-blind, placebo-controlled trial. J Am Acad Dermatol 2024; 90:1190. doi:10.1016/j.jaad.2023.12.066
- R Bissonnette et al. Efficacy and safety of delgocitinib cream in adults with moderate to severe chronic hand eczema (DELTA 1 and DELTA 2): results from multicentre, randomised, controlled, double-blind, phase 3 trials. Lancet 2024; 404:461. doi:10.1016/s0140-6736(24)01027-4
- M Gooderham et al. Long-term safety and efficacy of delgocitinib cream for up to 52 weeks in adults with chronic hand eczema: results of the phase 3 open-label extension DELTA 3 trial following the DELTA 1 and 2 trials. J Am Acad Dermatol 2025; 93:95. doi:10.1016/j.jaad.2025.03.008
- AM Giménez-Arnau et al. Efficacy and safety of topical delgocitinib cream versus oral alitretinoin capsules in adults with severe chronic hand eczema (DELTA FORCE): a 24-week, randomised, head-to-head, phase 3 trial. Lancet 2025; 405:1676. doi:10.1016/s0140-6736(25)00001-7
- In brief: New warnings for Janus kinase inhibitors. Med Lett Drugs Ther 2021; 63:160.
- Approximate WAC for a 30-gram tube. WAC = wholesaler acquisition cost or manufacturer's published price to wholesalers; WAC represents a published catalogue or list price and may not represent an actual transactional price. Source: AnalySource® Monthly. September 5, 2025. Reprinted with permission by First Databank, Inc. All rights reserved. ©2025. www.fdbhealth.com/policies/drug-pricing-policy.
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Title: Delgocitinib Cream (Anzupgo) for Chronic Hand Eczema
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