The Medical Letter on Drugs and Therapeutics
In Brief: PPIs and Hypomagnesemia
April 4, 2011 (Issue: 1361)The FDA has warned that prolonged use of a proton pump inhibitor (PPI) can lead to hypomagnesemia.1 Normal serum concentrations of magnesium are 0.7-1.0 mmol/L. About 30 cases of severe hypomagnesemia (<0.5 mmol/L) have been reported in long-term...more
1. FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs). Available at www.fda.gov/Drugs/DrugSafety/ucm245011.htm. Accessed March 28, 2011.
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